Skip to main content
TYRATyra Biosciences, Inc.Sell5.5·$26.99+5.55%
Open full analysis

Tyra Biosciences, Inc. (TYRA) Stock Analysis

SellModerate Confidence

Healthcare · Biotechnology

Sell if holding. Engine safety override at $26.99: Quality below floor (1.2 < 4.0) triggers a hard block regardless of the otherwise-positive setup — overall score 5.5/10 and A.R:R 4.6:1 is above the 1.5:1 BUY gate. Specifically: High short interest: 29%; Elevated put/call ratio: 88.00; Below-average business quality.

Tyra Biosciences is a clinical-stage oncology company developing oral FGFR inhibitors using its proprietary SNÅP platform, with lead program oral dabogratinib in Phase 2 trials for LG-UTUC (SURF303), IR NMIBC (SURF302), and achondroplasia (BEACH301). Two additional clinical... Read more

$26.99+66.3% A.UpsideScore 5.5/10#51 of 157 Biotechnology
QualityF-score2 / 9FCF yield-3.75%
Stop $25.10Target $44.89(analyst − 13%)A.R:R 4.6:1
Analyst target$51.60+91.2%11 analysts
$44.89our TP
$26.99price
$51.60mean
$60

Sell if holding. Engine safety override at $26.99: Quality below floor (1.2 < 4.0) triggers a hard block regardless of the otherwise-positive setup — overall score 5.5/10 and A.R:R 4.6:1 is above the 1.5:1 BUY gate. Specifically: High short interest: 29%; Elevated put/call ratio: 88.00; Below-average business quality. Chart setup: No clear chart pattern; technical signals are mixed. Score 5.5/10, moderate confidence.

Passes 8/9 gates (positive momentum, favorable risk/reward ratio, clean insider activity, no SEC red flags, news boost analyst cluster(9), earnings proximity 60d clear, semi cycle peak clear, materials cycle peak clear). Suitability: aggressive.

news + 30-day 8-K events · 5-min refresh

Recent developments

updated 2026-06-14

Recent Developments — Tyra Biosciences, Inc.

Generated 2026-06-15T18:11:47Z.

TrendMatrix Research · upcoming catalyst calendar

Upcoming dated catalysts

Thu, Aug 13, 202660d to earnings· next earnings call

Thesis

Rewards
Recent Analyst Cluster(9) detected in news
Risks
Quality below floor (1.2 < 4.0)

Key Metrics

P/E (TTM)
P/E (Fwd)-9.6
Mkt Cap$1.6B
EV/EBITDA-8.6
Profit Mgn0.0%
ROE-36.9%
Rev Growth
Beta0.75
DividendNone
Rating analysts21

Quality Signals

Piotroski F2/9

Options Flow

P/C88.00bearish
IV156%elevated
Max Pain$25-7.4% vs spot

Model-generated analysis — not investment advice. Not a registered investment advisor. Past performance does not guarantee future results.

Show full disclosure ▾

About TrendMatrix. TrendMatrix is a publisher of general securities research and market commentary. We publish on a regular schedule. All content is the same for every subscriber in a tier — we do not provide personalized investment advice and we do not take into account any individual subscriber's financial situation, investment objectives, risk tolerance, tax situation, or holdings.

Not investment advice. TrendMatrix is not a registered investment adviser. Our content is for informational and educational purposes only. Consult your own licensed investment adviser, broker, or tax professional before making any investment decision.

Conflicts and positions. The TrendMatrix editorial team frequently holds personal long-term positions in securities discussed. We disclose positions held at the time of publication on each piece. We maintain a trading-window policy: we do not initiate or close positions in the same direction as a TrendMatrix publication within 24 hours before or 72 hours after publication.

No paid promotion. TrendMatrix does not accept payment from any issuer, broker, or third party in exchange for coverage of any security. Our sole compensation is subscription revenue.

No fiduciary duty. No fiduciary, advisory, or agency relationship is created between you and TrendMatrix by reading our content or subscribing to our service.

Performance. Past performance is not indicative of future results. Performance figures reflect the published model only and do not reflect any individual subscriber's actual results.

Methodology · Editorial policy & full disclaimer

Rating Breakdown

2 floor-breakers·1 ceiling hit

Quality below the gate floor. Component breakdown shows what dragged the score down.static

Roe
0.0
Roa
0.0
Gross Margin
0.0
Operating Margin
0.0
Net Margin
0.0
Fcf Quality
0.0
Piotroski F
2.2
Moat
3.2
Current Ratio
5.0
Cash-burning (FCF negative)No competitive moatWeak Piotroski F-Score: 2/9Quality concerns

Volatile — 7.3% daily ATR makes tight stops impractical. Position-size conservatively.static

Days To Cover
0.0
Volatility
0.0
Put Call
0.0
Implied Vol
0.0
Short Interest
0.6
Debt Equity
4.1
Max Pain Risk
5.0
News Risk
5.0
Beta
8.5
High short interest justified: 29%Elevated put/call: 88.00High IV: 156%
GatesMomentum 5.2<5.5 (soft — BUY_NOW allowed but watch)Momentum 5.2>=4.5A.R:R 4.6 ≥ 1.5Insider activity: OKNo SEC red flagsNEWS BOOST ANALYST CLUSTER(9)EARNINGS PROXIMITY 60d clearSEMI CYCLE PEAK CLEARMATERIALS CYCLE PEAK CLEARSuitability: Aggressive
RSI
28 · Oversold
20D MA 50D MA 200D MAGOLDEN CROSSSupport $24.66Resistance $37.27

Price Targets

$25
$45
A.Upside+66.3%
A.R:R4.6:1

Position Sizing

ConvictionNone
Suggested %0.5%
Max %1%
RegimeSteady

Risk Alerts

! Quality below floor (1.2 < 4.0)

Earnings

B
B
M
M
2/4 beats
Next Earnings2026-08-13 (60d)

Verdict History

reverse chrono — latest first
Loading history...
Verdicts are recorded on every nightly pipeline run. Rows capture transitions (verdict flips, score deltas ≥0.3, entry/TP/SL changes). Rows with a ▶ can be expanded to see the change reason. Aggregate cohort performance is tracked in the recommendation ledger.
Frequently Asked Questions
Is TYRA stock a buy right now?

Sell if holding. Engine safety override at $26.99: Quality below floor (1.2 < 4.0) triggers a hard block regardless of the otherwise-positive setup — overall score 5.5/10 and A.R:R 4.6:1 is above the 1.5:1 BUY gate. Specifically: High short interest: 29%; Elevated put/call ratio: 88.00; Below-average business quality. Chart setup: No clear chart pattern; technical signals are mixed. Prior stop was $25.10. Score 5.5/10, moderate confidence.

What is the TYRA stock price target?

Take-profit target: $44.89 (+66.3% upside). Prior stop was $25.10. Stop-loss: $25.10.

What are the risks of investing in TYRA?

Quality below floor (1.2 < 4.0).

Is TYRA overvalued or undervalued?

Tyra Biosciences, Inc. trades at a P/E of N/A (forward -9.6). TrendMatrix value score: 9.0/10. Verdict: Sell.

What do analysts say about TYRA?

21 analysts cover TYRA with a consensus score of 4.3/5. Average price target: $52.

What does Tyra Biosciences, Inc. do?Tyra Biosciences is a clinical-stage oncology company developing oral FGFR inhibitors using its proprietary SNÅP...

Tyra Biosciences is a clinical-stage oncology company developing oral FGFR inhibitors using its proprietary SNÅP platform, with lead program oral dabogratinib in Phase 2 trials for LG-UTUC (SURF303), IR NMIBC (SURF302), and achondroplasia (BEACH301). Two additional clinical programs, TYRA-430 (FGFR4, Phase 1 for HCC) and TYRA-200 (FGFR1/2/3, Phase 1 for resistant ICC), round out the pipeline.

Related stocks: AUPH (Aurinia Pharmaceuticals Inc) · ADMA (ADMA Biologics Inc) · HRMY (Harmony Biosciences Holdings, I) · AAPG (Ascentage Pharma Group Internat) · TLX (Telix Pharmaceuticals Limited)
Home Stocks TYRA

Latest news

Latest News

Benzinga3d agoAnalyst
Benzinga4d agoAnalyst
Benzinga5d agoAnalyst
Benzinga5d agoAnalyst
Benzinga14d ago
Benzinga27d ago
Benzinga27d agoAnalyst
Benzinga27d agoAnalyst
Benzinga27d agoAnalyst
Benzinga32d agoAnalyst
Benzinga33d ago
Benzinga61d agoAnalyst
Benzinga61d ago
Benzinga70d ago