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Summit Therapeutics Inc. (SMMT) Stock Analysis

Range Bound setup

SellModerate Confidence

Healthcare · Biotechnology

Sell if holding. Engine safety override at $17.06: a dimension score below its floor triggers a hard block regardless of the otherwise-positive setup — overall score 4.9/10 and A.R:R 1.8:1 is above the 1.5:1 BUY gate. Specifically: High short interest: 26%; Below-average business quality.

Summit Therapeutics is a clinical-stage oncology biopharmaceutical company developing ivonescimab, a PD-1/VEGF-A bispecific antibody in-licensed from Akeso. A BLA was filed Q4 2025 for ivonescimab in EGFR-mutated NSCLC with a PDUFA date of November 14, 2026. Rights cover the US,... Read more

$17.06+26.4% A.UpsideScore 4.9/10#101 of 158 Biotechnology
Stop $19.96Target $27.13(analyst − 13%)A.R:R 1.8:1
Analyst target$31.19+82.8%14 analysts
$27.13our TP
$17.06price
$31.19mean
$12
$45

Sell if holding. Engine safety override at $17.06: a dimension score below its floor triggers a hard block regardless of the otherwise-positive setup — overall score 4.9/10 and A.R:R 1.8:1 is above the 1.5:1 BUY gate. Specifically: High short interest: 26%; Below-average business quality. Chart setup: RSI 57 mid-range, Bollinger mid-band. Score 4.9/10, moderate confidence.

Passes 7/9 gates (positive momentum, favorable risk/reward ratio, clean insider activity, no SEC red flags, news events none recent, earnings proximity no date, semi cycle peak clear). Suitability: moderate.

Thesis

Rewards
No bull case signals
Risks
Concentration risk — Product: ivonescimab
Concentration risk — Supplier: Akeso
Quality below floor (2.0 < 4.0)

Key Metrics

P/E (TTM)
P/E (Fwd)-18.2
Mkt Cap$16.7B
EV/EBITDA-14.6
Profit Mgn0.0%
ROE-206.1%
Rev Growth
Beta-1.37
DividendNone
Rating analysts23

Quality Signals

Piotroski F2/9

Options Flow

P/C1.16bearish
IV341%elevated
Max Pain$5-70.7% vs spot

Concentration Risks(10-K Item 1A)

  • HIGHProductivonescimab
    10-K Item 1A: 'We depend heavily on the success of ivonescimab'
  • HIGHSupplierAkeso
    10-K Item 1A: 'We depend on our relationship with, and the intellectual property licensed from Akeso'

Model-generated analysis — not investment advice. Not a registered investment advisor. Past performance does not guarantee future results. Full disclaimer

Rating Breakdown

4 floor-breakers·1 ceiling hit

Volatile — 8.5% daily ATR makes tight stops impractical. Position-size conservatively.static

Days To Cover
0.0
Volatility
0.0
Implied Vol
0.0
Short Interest
0.9
Debt Equity
1.8
Max Pain Risk
3.0
Put Call
5.6
High short interest justified: 26%High IV: 341%Above max pain $5Concentration risks: 2 HIGH (10-K Item 1A — sized via position_sizing, validated via buy_confidence)

Quality below the gate floor. Component breakdown shows what dragged the score down.static

Gross Margin
0.0
Operating Margin
0.0
Net Margin
0.0
Piotroski F
2.2
Current Ratio
5.0
Moat
5.0
No competitive moatWeak Piotroski F-Score: 2/9Quality concerns

No near-term catalyst priced in. Thesis progression will come from fundamentals grinding, not event reaction.static

Earnings History
0.0
Surprise Avg
0.0
Erm
3.5
News Activity
8.0
Earnings concerns: 0B/3M

Ranks in the bottom of its industry peers on the composite signal. Better names in the same sector exist.static

Quality Rank
0.0
Value Rank
5.0
Growth Rank
5.0
GatesMomentum 5.3<5.5 (soft — BUY_NOW allowed but watch)Death cross (50MA < 200MA)Momentum 5.3>=4.5A.R:R 1.8 ≥ 1.5Insider activity: OKNo SEC red flagsNEWS EVENTS NONE RECENTEARNINGS PROXIMITY NO DATESEMI CYCLE PEAK CLEARRange BoundSuitability: Moderate
RSI
57 · Neutral
20D MA 50D MA 200D MADEATH CROSSSupport $18.38Resistance $29.23

Price Targets

$20
$27
A.Upside+59.0%
A.R:R1.8:1

Position Sizing

ConvictionNone
Suggested %0.5%
Max %1%
RegimeSteady

Risk Alerts

! Quality below floor (2.0 < 4.0)

Earnings

M
M
M
M
0/4 beats
Next Earnings2026-04-30 (nulld)

Verdict History

reverse chrono — latest first
Loading history...
Verdicts are recorded on every nightly pipeline run. Rows capture transitions (verdict flips, score deltas ≥0.3, entry/TP/SL changes). Rows with a ▶ can be expanded to see the change reason. Aggregate cohort performance is tracked in the recommendation ledger.
Frequently Asked Questions
Is SMMT stock a buy right now?

Sell if holding. Engine safety override at $17.06: a dimension score below its floor triggers a hard block regardless of the otherwise-positive setup — overall score 4.9/10 and A.R:R 1.8:1 is above the 1.5:1 BUY gate. Specifically: High short interest: 26%; Below-average business quality. Chart setup: RSI 57 mid-range, Bollinger mid-band. Prior stop was $19.96. Score 4.9/10, moderate confidence.

What is the SMMT stock price target?

Take-profit target: $27.13 (+26.4% upside). Prior stop was $19.96. Stop-loss: $19.96.

What are the risks of investing in SMMT?

Concentration risk — Product: ivonescimab; Concentration risk — Supplier: Akeso; Quality below floor (2.0 < 4.0).

Is SMMT overvalued or undervalued?

Summit Therapeutics Inc. trades at a P/E of N/A (forward -18.2). TrendMatrix value score: 9.0/10. Verdict: Sell.

What do analysts say about SMMT?

23 analysts cover SMMT with a consensus score of 3.9/5. Average price target: $31.

What does Summit Therapeutics Inc. do?Summit Therapeutics is a clinical-stage oncology biopharmaceutical company developing ivonescimab, a PD-1/VEGF-A...

Summit Therapeutics is a clinical-stage oncology biopharmaceutical company developing ivonescimab, a PD-1/VEGF-A bispecific antibody in-licensed from Akeso. A BLA was filed Q4 2025 for ivonescimab in EGFR-mutated NSCLC with a PDUFA date of November 14, 2026. Rights cover the US, Canada, EU, Japan, and expanded territories.

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