Opko Health shows an extremely favorable risk/reward asymmetry ahead of an upcoming earnings catalyst, but cash burn, a steep revenue decline, and heavy options hedging keep quality deeply below the engine's floor.
Thesis pillars
- Elevated Options Hedging↑Improving
- High Asymmetry Catalyst Edge↑Improving
- Quality Floor Breach↑Improving
- +2 more pillars — see the Why tab for full reasoning
Opko Health, Inc. (OPK) Stock Analysis
Range Bound setup · Inst Constrain edge
Healthcare · Diagnostics & Research
Sell if holding. Engine safety override at $1.36: a dimension score below its floor triggers a hard block regardless of the otherwise-positive setup — overall score 5.7/10. Specifically: Below-average business quality.
OPKO Health, Inc. operates as a healthcare company, in the United States, Ireland, Chile, Spain, Israel, Mexico, and internationally. The company operates in two segments, Pharmaceutical and Diagnostics. The Pharmaceutical segment develops MDX2001, a tetra-specific antibody... Read more
Sell if holding. Engine safety override at $1.36: a dimension score below its floor triggers a hard block regardless of the otherwise-positive setup — overall score 5.7/10. Specifically: Below-average business quality. Chart setup: RSI 49 mid-range, Bollinger mid-band. Score 5.7/10, moderate confidence.
Passes 7/8 gates (positive momentum, clean insider activity, no SEC red flags, news events none recent, earnings proximity 91d clear, semi cycle peak clear, materials cycle peak clear). Suitability: aggressive.
Recent developments
updated 2026-07-29Recent Developments — Opko Health, Inc.
Latest news
- NEWS 12 Health Care Stocks Moving In Tuesday's Intraday Session — benzinga Jul 28, 2026 neutral
- NEWS Crude Oil Down Over 5%; Boeing Shares Rise After Q2 Results — benzinga Jul 28, 2026 neutral
- NEWS Sherwin-Williams Posts Upbeat Q2 Earnings, Joins Itron, Armstrong World And Other Big Stocks Moving Higher On Tuesday — benzinga Jul 28, 2026 neutral
- NEWS Why Celestica Shares Are Trading Higher By Around 5%; Here Are 20 Stocks Moving Premarket — benzinga Jul 28, 2026 neutral
- NEWS 12 Health Care Stocks Moving In Monday's After-Market Session — benzinga Jul 27, 2026 neutral
Generated 2026-07-31T00:08:42Z.
Upcoming dated catalysts
Thesis
Key Metrics
Quality Signals
Options Flow
Concentration Risks(10-K Item 1A)
- HIGHGeographicNew York and New Jersey10-K Item 1: 'Our clinical and women's health testing services are concentrated in New York and New Jersey.'
- HIGHcounterpartyPfizer10-K Item 1A: 'Our exclusive worldwide agreement with Pfizer is important to our business.'
Model-generated analysis — not investment advice. Not a registered investment advisor. Past performance does not guarantee future results.
Show full disclosure ▾Hide full disclosure ▴
About TrendMatrix. TrendMatrix is a publisher of general securities research and market commentary. We publish on a regular schedule. All content is the same for every subscriber in a tier — we do not provide personalized investment advice and we do not take into account any individual subscriber's financial situation, investment objectives, risk tolerance, tax situation, or holdings.
Not investment advice. TrendMatrix is not a registered investment adviser. Our content is for informational and educational purposes only. Consult your own licensed investment adviser, broker, or tax professional before making any investment decision.
Conflicts and positions. The TrendMatrix editorial team frequently holds personal long-term positions in securities discussed. We disclose positions held at the time of publication on each piece. We maintain a trading-window policy: we do not initiate or close positions in the same direction as a TrendMatrix publication within 24 hours before or 72 hours after publication.
No paid promotion. TrendMatrix does not accept payment from any issuer, broker, or third party in exchange for coverage of any security. Our sole compensation is subscription revenue.
No fiduciary duty. No fiduciary, advisory, or agency relationship is created between you and TrendMatrix by reading our content or subscribing to our service.
Performance. Past performance is not indicative of future results. Performance figures reflect the published model only and do not reflect any individual subscriber's actual results.
Rating Breakdown
2 floor-breakers·1 ceiling hit
Unprofitable operations — net margin -12.4%. Quality floor flags this regardless of sector context.static
Growth below the gate floor. Component breakdown shows what dragged the score down.static
Price Targets
Position Sizing
Risk Alerts
Earnings
Verdict History
Frequently Asked Questions
Sell if holding. Engine safety override at $1.36: a dimension score below its floor triggers a hard block regardless of the otherwise-positive setup — overall score 5.7/10. Specifically: Below-average business quality. Chart setup: RSI 49 mid-range, Bollinger mid-band. Prior stop was $1.27. Score 5.7/10, moderate confidence.
Take-profit target: $1.70 (+24.5% upside). Prior stop was $1.27. Stop-loss: $1.27.
Concentration risk — Geographic: New York and New Jersey; Concentration risk — Counterparty: Pfizer; DATA_ISSUE: analyst_target_implausible (raw $4.38 vs price $1.36 — ratio 3.2×). Rejected, falling back to technical TP..
Opko Health, Inc. trades at a P/E of N/A (forward -6.3). TrendMatrix value score: 8.9/10. Verdict: Sell.
10 analysts cover OPK with a consensus score of 3.9/5. Average price target: $4.
What does Opko Health, Inc. do?OPKO Health, Inc. operates as a healthcare company, in the United States, Ireland, Chile, Spain, Israel, Mexico, and...
OPKO Health, Inc. operates as a healthcare company, in the United States, Ireland, Chile, Spain, Israel, Mexico, and internationally. The company operates in two segments, Pharmaceutical and Diagnostics. The Pharmaceutical segment develops MDX2001, a tetra-specific antibody targeting several types of solid tumors in Phase 1 clinical trials; MDX2003, a tetra-specific antibody targeting two antigens for hematological tumors in Phase 1 clinical trials; and MDX2004, a trispecific immune modulator to rebuild and sustain the patient's own immune system. This segment also engages in the development of Epstein Barr Virus vaccine; Rayaldee, a patented extended-release product for oral administration containing 30 mcg of a prohormone; OPK-88006 oral and injectable product to regulate blood glucose and reduce body weight; NGENLA, recombinant human growth hormone product developed for the long-term treatment of pediatric patients with growth hormone deficiency. The Diagnostics segment offers laboratory testing services, such as detection, diagnosis, evaluation, monitoring, and treatment of diseases, as well as esoteric testing, molecular diagnostics, anatomical pathology, genetics, women's health, and correctional healthcare under the BioReference brand; and 4Kscore test. OPKO Health, Inc. was founded in 2006 and is headquartered in Miami, Florida.