Tango Therapeutics, Inc. (TNGX) Stock Analysis
Breakout setup
Healthcare · Biotechnology
Sell if holding. Engine safety override at $28.66: a dimension score below its floor triggers a hard block regardless of the otherwise-positive setup — overall score 4.5/10. Specifically: High short interest: 23%; Elevated put/call ratio: 2.22; Below-average business quality.
Tango Therapeutics is a clinical-stage precision oncology company developing MTA-cooperative PRMT5 inhibitors for MTAP-deleted cancers. Its lead program vopimetostat showed 27% ORR across cancer types in Phase 1/2 with a pivotal 2L pancreatic cancer trial planned for 2026;... Read more
Sell if holding. Engine safety override at $28.66: a dimension score below its floor triggers a hard block regardless of the otherwise-positive setup — overall score 4.5/10. Specifically: High short interest: 23%; Elevated put/call ratio: 2.22; Below-average business quality. Chart setup: Golden cross, above all MAs, RSI 65, MACD bullish. Score 4.5/10, moderate confidence.
Passes 6/8 gates (positive momentum, clean insider activity, news events none recent, earnings proximity 55d clear, semi cycle peak clear, materials cycle peak clear). Fails on favorable risk/reward ratio. Suitability: aggressive.
Recent developments
updated 2026-06-11Recent Developments — Tango Therapeutics, Inc.
Latest news
- NEWS Reported Earlier, Tango Therapeutics Prices Upsized $600M Public Offering Of 18,166,667 Common Shares And 1,833,395 Pre- — benzinga Jun 10, 2026 positive
- NEWS HC Wainwright & Co. Maintains Buy on Tango Therapeutics, Raises Price Target to $66 — benzinga Jun 9, 2026 neutral
- NEWS Apple, SUNation Energy, Tango Therapeutics, Applied Digital And Cerebras Systems: Why These 5 Stocks Are On Investors' R — benzinga Jun 8, 2026 positive
- NEWS Tango Therapeutics Launches $500M Common Stock Offering — benzinga Jun 8, 2026 negative
- NEWS 12 Health Care Stocks Moving In Monday's Intraday Session — benzinga Jun 8, 2026 neutral
Generated 2026-06-15T18:11:47Z.
Upcoming dated catalysts
Thesis
Key Metrics
Quality Signals
Options Flow
Concentration Risks(10-K Item 1A)
- HIGHpipelinevopimetostat10-K Item 1: 'vopimetostat (TNG462) for non-CNS cancers...supporting the planned initiation of a 2L pivotal trial in this patient population in 2026.'
- HIGHSupplierone manufacturer (drug substance)10-K Item 1: 'all manufacturing of the drug substance for our product candidates to be used in our clinical trials is conducted by one manufacturer'
Material Events(8-K, last 90d)
- 2026-04-15Item 5.02MEDIUMCFO Daniella Beckman terminated effective April 15, 2026; Matthew Gall appointed successor CFO same day. No reason cited for Beckman's departure. Gall previously CFO at Kalaris Therapeutics and iTeos Therapeutics.SEC filing →
- 2026-05-08Item 5.02LOWSeparation agreement with former CFO Daniella Beckman executed May 7, 2026: 12 months severance, COBRA reimbursement up to 12 months, accelerated 24-month forward equity vesting, options extended through August 31, 2026.SEC filing →
Model-generated analysis — not investment advice. Not a registered investment advisor. Past performance does not guarantee future results.
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Rating Breakdown
4 floor-breakers
Unprofitable operations — net margin -188.2%. Quality floor flags this regardless of sector context.static
Volatile — 8.5% daily ATR makes tight stops impractical. Position-size conservatively.static
Ranks in the bottom of its industry peers on the composite signal. Better names in the same sector exist.static
Technicals below the gate floor. Component breakdown shows what dragged the score down.static
Price Targets
Position Sizing
Risk Alerts
Earnings
Verdict History
Frequently Asked Questions
Sell if holding. Engine safety override at $28.66: a dimension score below its floor triggers a hard block regardless of the otherwise-positive setup — overall score 4.5/10. Specifically: High short interest: 23%; Elevated put/call ratio: 2.22; Below-average business quality. Chart setup: Golden cross, above all MAs, RSI 65, MACD bullish. Prior stop was $27.01. Score 4.5/10, moderate confidence.
Take-profit target: $32.11 (+10.6% upside). Prior stop was $27.01. Stop-loss: $27.01.
Concentration risk — Pipeline: vopimetostat; Concentration risk — Supplier: one manufacturer (drug substance); Quality below floor (1.7 < 4.0).
Tango Therapeutics, Inc. trades at a P/E of N/A (forward -18.2). TrendMatrix value score: 6.0/10. Verdict: Sell.
18 analysts cover TNGX with a consensus score of 4.1/5. Average price target: $37.
What does Tango Therapeutics, Inc. do?Tango Therapeutics is a clinical-stage precision oncology company developing MTA-cooperative PRMT5 inhibitors for...
Tango Therapeutics is a clinical-stage precision oncology company developing MTA-cooperative PRMT5 inhibitors for MTAP-deleted cancers. Its lead program vopimetostat showed 27% ORR across cancer types in Phase 1/2 with a pivotal 2L pancreatic cancer trial planned for 2026; TNG456 targets GBM. The company has no approved products or product revenue and had an accumulated deficit of $603.2 million as of December 31, 2025.