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BeOne Medicines Ltd. (ONC) Stock Analysis

Recovery setup

Buy Now (conditional)Moderate Confidence

Conditional: analysts disagree (1.5× target spread) — below strong-conviction threshold. Size accordingly.

Healthcare · Biotechnology

Buy at $315.55 (limit $312.12). A.R:R 2.6:1 at $315.55 — the engine's gate value (upside to target $370.14 vs. downside set by the wider of 2×ATR or distance-to-support, clipped 5-15%). You'd stand to gain ~$55 per share to target. Key risk: Concentration risk — Product: BRUKINSA.

BeOne Medicines is a global oncology company that generated approximately $5.3 billion in total revenue in 2025, a 40.2% increase year-over-year. BRUKINSA, its BTK inhibitor approved in over 75 markets, became the global market leader across B-cell malignancies and generated... Read more

$315.55+18.6% A.UpsideScore 6.8/10#5 of 157 Biotechnology
QualityF-score9 / 9FCF yield2.83%
Entry $312.12(at market)Stop $296.26Target $370.14(analyst − 10%)A.R:R 2.6:1
Analyst target$411.27+30.3%27 analysts
$370.14our TP
$315.55price
$411.27mean
$501

Buy at $315.55 (limit $312.12). A.R:R 2.6:1 at $315.55 — the engine's gate value (upside to target $370.14 vs. downside set by the wider of 2×ATR or distance-to-support, clipped 5-15%). You'd stand to gain ~$55 per share to target. Key risk: Concentration risk — Product: BRUKINSA. Chart setup: Death cross but MACD improving, RSI 45. Growth is outpacing valuation and the chart agrees (PEG 0.00, quality 7.5/10, growth 10.0/10). Score 6.8/10, moderate confidence.

Passes 8/8 gates (positive momentum, favorable risk/reward ratio, clean insider activity, no SEC red flags, news boost analyst 0.70, news boost analyst cluster(3), earnings proximity 86d clear, semi cycle peak clear). Suitability: moderate.

Thesis

Rewards
Strong earnings beat streak (3/4)
High-quality business
Strong growth profile
Risks
Concentration risk — Product: BRUKINSA

Key Metrics

P/E (TTM)70.5
P/E (Fwd)34.5
Mkt Cap$32.4B
EV/EBITDA542.1
Profit Mgn8.9%
ROE12.4%
Rev Growth35.5%
Beta0.50
DividendNone
Rating analysts15

Quality Signals

Piotroski F9/9MoatWideCompounder

Options Flow

P/C2.25bearish
IV78%elevated
Max Pain$260-17.6% vs spot

Concentration Risks(10-K Item 1A)

  • HIGHProductBRUKINSA
    10-K Item 1A: 'BRUKINSA generated $3.9 billion in sales in 2025'

Model-generated analysis — not investment advice. Not a registered investment advisor. Past performance does not guarantee future results. Full disclaimer

Rating Breakdown

1 ceiling hit

GatesMomentum 7.0>=5.5A.R:R 2.6 ≥ 1.5Insider activity: OKNo SEC red flagsNEWS BOOST ANALYST 0.70NEWS BOOST ANALYST CLUSTER(3)EARNINGS PROXIMITY 86d clearSEMI CYCLE PEAK CLEARRecoverySuitability: Moderate
RSI
45 · Neutral
20D MA 50D MA 200D MADEATH CROSSSupport $289.54Resistance $328.39

Price Targets

$296
$312
$370
A.Upside+17.3%
A.R:R2.6:1
Setup A.R:R (at entry)3.6:1

Position Sizing

ConvictionHigh conviction
Suggested %2.1%
Max %4.2%
RegimeCautious

Analyst Consensus

Analysts15
Consensus4.1/5
Avg Target$411

Earnings

B
B
B
M
3/4 beats
Next Earnings2026-08-05 (86d)

Verdict History

reverse chrono — latest first
Loading history...
Verdicts are recorded on every nightly pipeline run. Rows capture transitions (verdict flips, score deltas ≥0.3, entry/TP/SL changes). Rows with a ▶ can be expanded to see the change reason. Aggregate cohort performance is tracked in the recommendation ledger.
Frequently Asked Questions
Is ONC stock a buy right now?

Buy at $315.55 (limit $312.12). A.R:R 2.6:1 at $315.55 — the engine's gate value (upside to target $370.14 vs. downside set by the wider of 2×ATR or distance-to-support, clipped 5-15%). You'd stand to gain ~$55 per share to target. Key risk: Concentration risk — Product: BRUKINSA. Chart setup: Death cross but MACD improving, RSI 45. Growth is outpacing valuation and the chart agrees (PEG 0.00, quality 7.5/10, growth 10.0/10). Target $370.14 (+17.3%), stop $296.26 (−6.5%), A.R:R 2.6:1. Score 6.8/10, moderate confidence.

What is the ONC stock price target?

Take-profit target: $370.14 (+18.6% upside). Target $370.14 (+17.3%), stop $296.26 (−6.5%), A.R:R 2.6:1. Stop-loss: $296.26.

What are the risks of investing in ONC?

Concentration risk — Product: BRUKINSA.

Is ONC overvalued or undervalued?

BeOne Medicines Ltd. trades at a P/E of 70.5 (forward 34.5). TrendMatrix value score: 5.7/10. Verdict: Strong Buy.

What do analysts say about ONC?

15 analysts cover ONC with a consensus score of 4.1/5. Average price target: $411.

What does BeOne Medicines Ltd. do?BeOne Medicines is a global oncology company that generated approximately $5.3 billion in total revenue in 2025, a...

BeOne Medicines is a global oncology company that generated approximately $5.3 billion in total revenue in 2025, a 40.2% increase year-over-year. BRUKINSA, its BTK inhibitor approved in over 75 markets, became the global market leader across B-cell malignancies and generated $3.9 billion in 2025 sales. The company reported net income of $286.9 million and positive free cash flow of $941.7 million.

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